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Hongwei Jin, Ph.D.

Associate Director, Cardiovascular Biology and Mouse Physiology

Expert in in vivo physiology and pharmacology.

Location

Bar Harbor, ME

Contact

207-288-6034

[email protected]

Dr. Hongwei Jin has extensive experience in electrophysiology and pharmacology. He applies his expertise to build in vivo mouse physiology platforms for screening cardiovascular, vision, hearing, sleeping, and various type of genetic disorders; and for drug efficacy tests in mouse disease models. Dr. Jin has authored and co-authored over 20 peer-reviewed publications.

Selected Publications

24Jin H, Welzig CM, Aronovitz M, Noubary F, Blanton R, Wang B, Rajab M, Albano A, Link MS, Noujaim SF, Park HJ, Galper JB. QRS/T-wave and calcium alternans in a type I diabetic mouse model for spontaneous postmyocardial infarction ventricular tachycardia: A mechanism for the antiarrhythmic effect of statins. Heart Rhythm. 2017 Sep; 14(9):1406-1416
33Rajab M, Jin H, Welzig CM, Albano A, Aronovitz M, Zhang Y, Park HJ, Link MS, Noujaim SF, Galper JB. Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: effect of pravastatin. Am J Physiol Heart Circ Physiol. 2013 Dec; 305(12):H1807-16
32Dvir T, Timko BP, Brigham MD, Naik SR, Karajanagi SS, Levy O, Jin H, Parker KK, Langer R, Kohane DS. Nanowired three-dimensional cardiac patches. Nat Nanotechnol. 2011 Sep 25; 6(11):720-5
48Jin H, Hadri L, Palomeque J, Morel C, Karakikes I, Kaprielian R, Hajjar R, Lebeche D. KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling. J Mol Cell Cardiol. 2010 Jun; 48(6):1169-79
32Jin H, Nass RD, Joudrey PJ, Lyon AR, Chemaly ER, Rapti K, Akar FG. Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart. Biophys J. 2010 May 19; 98(10):2063-71
32Jin H, Chemaly ER, Lee A, Kho C, Hadri L, Hajjar RJ, Akar FG. Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy. FASEB J. 2010 Feb; 24(2):451-63
24Takewa Y, Chemaly ER, Takaki M, Liang LF, Jin H, Karakikes I, Morel C, Taenaka Y, Tatsumi E, Hajjar RJ. Mechanical work and energetic analysis of eccentric cardiac remodeling in a volume overload heart failure in rats. Am J Physiol Heart Circ Physiol. 2009 Apr; 296(4):H1117-24
Jin H, Lyon AR, Akar FG. Arrhythmia mechanisms in the failing heart. Pacing Clin Electrophysiol. 2008 Aug; 31(8):1048-56
Kawase Y, Ly HQ, Prunier F, Lebeche D, Shi Y, Jin H, Hadri L, Yoneyama R, Hoshino K, Takewa Y, Sakata S, Peluso R, Zsebo K, Gwathmey JK, Tardif JC, Tanguay JF, Hajjar RJ. Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure. J Am Coll Cardiol. 2008 Mar 18; 51(11):1112-9
Albert CM, Nam EG, Rimm EB, Jin HW, Hajjar RJ, Hunter DJ, MacRae CA, Ellinor PT. Cardiac sodium channel gene variants and sudden cardiac death in women. Circulation. 2008 Jan 1; 117(1):16-23
Ayata C, Jin H, Kudo C, Dalkara T, Moskowitz MA. Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol. 2006 Apr; 59(4):652-61
Zhang HX, Zhang W, Jin HW, Wang XL. Galantamine blocks cloned Kv2.1, but not Kv1.5 potassium channels. Brain Res Mol Brain Res. 2004 Nov 24; 131(1-2):136-40

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Hongwei Jin, Ph.D.

Associate Director, Cardiovascular Biology and Mouse Physiology

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Selected Publications