For the rarest of rare genetic conditions, a one-of-a-kind mouse could light a path to new treatments.
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For the rarest of rare genetic conditions, a one-of-a-kind mouse could light a path to new treatments.
DAPT, a drug that reduces β amyloid levels in the brains of Alzheimer's disease patients, ameliorates cognitive defects in the Ts65Dn Down syndrome mouse model.
Conventional thinking has been that Down syndrome phenotypes are caused by over-expression of trisomy chr 21 genes. However, gene under-expression is also partly to blame.
Learn about the link between Dscr1 and Dyrk1a overexpression and reduced cancer incidences in Down syndrome patients and mouse models.